The effects of FoxO deficiency in mice
- Published: Jun 1, 2018
- Read Time: 1 minute
A new study may have revealed a possible new prevention and treatment strategy for osteoarthritis, which is one of the most common and debilitating age-related diseases in the United States.
Researchers suggest that increasing levels of FoxO proteins could be one way to prevent and treat osteoarthritis.
Researchers at The Scripps Research Institute (TSRI) in San Diego, CA, reveal that proteins called FoxO are key for joint health.
By boosting the levels of these FoxO proteins, they believe that it might be possible to treat osteoarthritis, or even stop the disease from developing.
Senior study author Dr. Martin Lotz — from the Department of Molecular Medicine at TSRI — and his team recently reported their results in the journal Science Translational Medicine.
The condition is characterized by a breakdown of cartilage, which is the tissue that cushions the joints of the bones. Osteoarthritis most commonly affects the knee, hip, and hand joints.
In a previous study, Dr. Lotz and team found that FoxO levels in joint cartilage are reduced. For this latest study, the researchers sought to find out more about how FoxO proteins affect joint health.
The researchers reached their findings by studying mice that were lacking FoxO proteins in their joint cartilage. Compared with control mice, the scientists found that FoxO-deficient mice experienced degeneration of the joints at a significantly younger age.
What is more, the rodents with FoxO deficiency showed greater susceptibility to cartilage damageduring a treadmill test, and they were also more likely to develop post-traumatic osteoarthritis due to knee injury.